Index › Hématopoïétique – myéloïde › Tissue macrophage (pan)
Tissue macrophage (pan)
Pan-macrophage identity shared by tissue-resident macrophages; tissue-specific programs are layered on top.
Marqueurs (10)
| Gène | Polarité | Protéine | Niveau | Spécificité | Espèce | Références |
|---|---|---|---|---|---|---|
| ADGRE1 | positif | F4/80 | mRNA, protein | pan-lignée | mouse | 23023392 |
| C1QA | positif | C1q A chain | mRNA | pan-lignée | human, mouse | 23023392 |
| CD68 | positif | CD68 | mRNA, protein | pan-lignée | human, mouse | 23023392 |
| CSF1R | positif | CD115 | mRNA, protein | pan-lignée | human, mouse | 23023392 |
| CX3CR1 | positif | CX3CR1 | mRNA, protein | pan-lignée | human, mouse | 23023392 |
| FCGR1A | positif | CD64 (FcgRI) | mRNA, protein | pan-lignée | human, mouse | 23023392 |
| MAFB | positif | MafB | mRNA | pan-lignée | human, mouse | 23023392 |
| MERTK | positif | MerTK | mRNA, protein | pan-lignée | human, mouse | 23023392 |
| FLT3 | négatif | FLT3 | mRNA | exclusion | mouse | 25033907 |
| ZBTB46 | négatif | zDC | mRNA | exclusion | mouse | 25033907 |
Sous-types
- Cardiac resident CCR2- macrophage
- Cardiac CCR2+ monocyte-derived macrophage
- Synovial MerTK+ TREM2-high macrophage
- Synovial MerTK+ LYVE1+ macrophage
- Synovial lining barrier macrophage (CX3CR1+)
- Lyve1-high MHCII-low interstitial macrophage
- Lyve1-low MHCII-high interstitial macrophage
- Lymph node subcapsular sinus macrophage
- Lymph node medullary sinus macrophage
- Splenic red pulp macrophage
- Bone marrow VCAM1+ F4/80+ macrophage (iron-recycling)
- Lipid-associated macrophage (LAM), adipose
- Ly6c+ adipose tissue macrophage (non-CLS)
- Hepatic lipid-associated macrophage (SPP1+), MAFLD
- Scar-associated macrophage (SAM), fibrotic liver
- Alveolar macrophage
- Microglia (core identity; neural detail elsewhere)
- Large peritoneal macrophage (GATA6+)
- Small peritoneal macrophage (MHC-II-high)
- Splenic marginal-zone macrophage
- M1 / classically activated macrophage (state)
- M2 / alternatively activated macrophage (state)
- Tumor-associated macrophage (TAM)