Index › Épithéliums respiratoire et digestif › Alveolar epithelial cell (pan-lineage)
Alveolar epithelial cell (pan-lineage)
Distal lung epithelium forming the gas-exchange surface.
Marqueurs (6)
| Gène | Polarité | Protéine | Niveau | Spécificité | Espèce | Références |
|---|---|---|---|---|---|---|
| CDH1 | positif | E-cadherin | mRNA, protein | pan-lignée | human, mouse | 33208946 32832598 |
| CLDN18 | positif | Claudin-18 | mRNA, protein | pan-lignée | human, mouse | 24739965 33208946 |
| EPCAM | positif | EpCAM (CD326) | mRNA, protein | pan-lignée | human, mouse | 33208946 24739965 |
| NKX2-1 | positif | NKX2-1 (TTF-1) | mRNA, protein | pan-lignée | human, mouse | 33208946 24739965 37291214 |
| PECAM1 | négatif | CD31 | mRNA, protein | exclusion | human, mouse | 33208946 24739965 |
| PTPRC | négatif | CD45 | mRNA, protein | exclusion | human, mouse | 33208946 24739965 |
Sous-types
- Lineage-negative epithelial progenitor (LNEP)
- Alveolar type-0 (AT0) cell
- hAEC2-derived alveolar metaplastic KRT5+ basal cell
- Ectopic distal MUC5B+ secretory cell (IPF)
- Alveolar type 2 (AT2) cell
- Alveolar type 1 (AT1) cell
- Terminal respiratory bronchiole secretory cell (TRB-SC / RAS cell / AT0)
- Transitional AT2-to-AT1 cell (DATP / PATS / KRT8+ ADI)
- Aberrant basaloid cell (IPF)