Index › Hématopoïétique – myéloïde › Hematopoietic stem and progenitor cell (lineage-negative) › Common myeloid progenitor (CMP) › Granulocyte-monocyte progenitor (GMP) › Mast cell progenitor (MCP) › Mast cell

Mast cell

Tissue-resident granulated effector cell expressing KIT and FcepsilonRI; heterogeneous across tissues.

Synonymes : tissue mast cell

Tissus : skin, gut, lung, connective tissue

Cell Ontology : mast cell · CL:0000097 (correspondance exacte) — A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-hi

Marqueurs (8)

Sous-types

• CD38+ CD117+ intermediate proliferative mast cell (nasal polyp)
• Human mast cell state MC1 (lung/bladder-enriched)
• Human mast cell state MC2 (intestine, cytokine-high)
• Human mast cell state MC5 (chymase/cathepsin G/IL5RA)
• Mucosal-type mast cell (MCT)
• Connective-tissue-type mast cell (MCTC)

Données curées avec références PubMed/DOI, licence CC BY 4.0. « Spécifique » est calculé sur la couverture de cet atlas : vérifiez dans la littérature citée. Version interactive avec filtres et comparaison.