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Exhausted CD8 T cell (terminal Tex)

CD8 T cell with sustained inhibitory receptor expression and impaired function in chronic infection or cancer.

Synonymes : Tex, exhausted CD8 T cell, terminally exhausted

Tissus : tumour, chronically infected tissue

Cell Ontology : CD8-positive exhausted alpha-beta T cell · CL:0020031 (correspondance exacte) — A CD8-positive alpha-beta T cell that displays impaired function and altered differentiation as a result of chronic antigenic stimulation (e.g., chronic infection, tumours, or persistent inflammation). This state is characterised by sustained expression of PD-1 as a shared feature. Additional exhaustion-associated molecules, including expression of the transcription factor TOX and reduced T-bet, a

Marqueurs (13)

Sous-types

• Intermediate exhausted CD8 T cell (Tex-int)
• Terminally exhausted CD8 T cell (Tex-term)
• Progenitor exhausted CD8 T cell (TCF1+ Tpex)

Données curées avec références PubMed/DOI, licence CC BY 4.0. « Spécifique » est calculé sur la couverture de cet atlas : vérifiez dans la littérature citée. Version interactive avec filtres et comparaison.