Index › Mésenchymateux – stromal, squelettique et adipeux › Fibroblast (pan-tissue) › Cancer-associated fibroblast (CAF) › CAF-S1 (FAP-high myofibroblastic CAF, breast)
CAF-S1 (FAP-high myofibroblastic CAF, breast)
Immunosuppressive FAP-high alpha-SMA-high CAF subset enriched in triple-negative breast cancer that attracts and retains CD25+FOXP3- T cells and promotes Tregs.
Marqueurs (9)
| Gène | Polarité | Protéine | Niveau | Spécificité | Espèce | Références |
|---|---|---|---|---|---|---|
| FAP | positif | FAP | mRNA, protein | défini | human | 29455927 32434947 |
| ACTA2 | positif | alpha-SMA | mRNA, protein | enrichi | human | 29455927 |
| CD276 | positif | B7-H3 | mRNA, protein | enrichi | human | 29455927 |
| CXCL12 | positif | CXCL12 | mRNA, protein | enrichi | human | 29455927 |
| DPP4 | positif | CD26 | mRNA, protein | enrichi | human | 29455927 |
| JAM2 | positif | JAM2 | mRNA, protein | enrichi | human | 29455927 |
| NT5E | positif | CD73 | mRNA, protein | enrichi | human | 29455927 |
| PDCD1LG2 | positif | PD-L2 | mRNA, protein | enrichi | human | 29455927 |
| TNFSF4 | positif | OX40L | mRNA, protein | enrichi | human | 29455927 |