Index › Mésenchymateux – stromal, squelettique et adipeux › Fibroblast (pan-tissue) › Cancer-associated fibroblast (CAF)
Cancer-associated fibroblast (CAF)
Activated fibroblasts of the tumour microenvironment, heterogeneous (myCAF, iCAF, apCAF).
Marqueurs (11)
| Gène | Polarité | Protéine | Niveau | Spécificité | Espèce | Références |
|---|---|---|---|---|---|---|
| ACTA2 | positif | alpha-SMA | mRNA, protein | enrichi | human, mouse | 28232471 |
| FAP | positif | FAP-alpha | mRNA, protein | enrichi | human, mouse | 31197017 28232471 |
| PDGFRA | positif | PDGFR-alpha | mRNA, protein | enrichi | human, mouse | 31197017 28232471 |
| PDPN | positif | Podoplanin | mRNA, protein | enrichi | human, mouse | 31197017 |
| S100A4 | positif | FSP1 | mRNA, protein | sous-ensemble | human, mouse | 28232471 |
| COL1A1 | positif | Collagen I alpha1 | mRNA, protein | pan-lignée | human, mouse | 31197017 |
| DCN | positif | Decorin | mRNA | pan-lignée | human, mouse | 31197017 |
| LUM | positif | Lumican | mRNA | pan-lignée | human, mouse | 31197017 |
| EPCAM | négatif | EpCAM | mRNA, protein | exclusion | human, mouse | 31197017 |
| PECAM1 | négatif | CD31 | mRNA, protein | exclusion | human, mouse | 31197017 |
| PTPRC | négatif | CD45 | mRNA, protein | exclusion | human, mouse | 31197017 |
Sous-types
- CAF-S1 (FAP-high myofibroblastic CAF, breast)
- CAF-S2 (FAP-negative, alpha-SMA-negative CAF, breast)
- CAF-S3 (FAP-negative, alpha-SMA-intermediate CAF, breast)
- CAF-S4 (alpha-SMA-high FAP-low myofibroblastic CAF, breast)
- Vascular CAF (vCAF, breast mouse model)
- S100A4+ CAF (breast mouse tumours)
- PDPN+ CAF (breast mouse tumours)
- Myofibroblastic CAF (myCAF)
- Inflammatory CAF (iCAF)
- Antigen-presenting CAF (apCAF)