Index › Hématopoïétique – myéloïde › Hematopoietic stem and progenitor cell (lineage-negative) › Common myeloid progenitor (CMP) › Granulocyte-monocyte progenitor (GMP) › Committed neutrophil progenitor (preNeu / proNeu) › Neutrophil promyelocyte › Neutrophil myelocyte / metamyelocyte › Immature (band) neutrophil › Mature neutrophil › Aged (senescent) neutrophil, CXCR4hi CD62Llo
Aged (senescent) neutrophil, CXCR4hi CD62Llo
Circulating neutrophil that has aged: loses CD62L, upregulates CXCR4, homes back to marrow; expanded in human stroke and Alzheimer disease.
Marqueurs (5)
| Gène | Polarité | Protéine | Niveau | Spécificité | Espèce | Références |
|---|---|---|---|---|---|---|
| CXCR4 | positif | CXCR4 | mRNA, protein | défini | human, mouse | 14563322 23706740 30709741 29369398 31355307 |
| SELL | négatif | CD62L (L-selectin) | mRNA, protein | défini | human, mouse | 23706740 29369398 31355307 30709741 |
| CXCR2 | positif | CXCR2 | mRNA, protein | sous-ensemble | mouse | 30709741 14563322 |
| ITGAM | positif | CD11b | protein | sous-ensemble | human | 31355307 |
| LY6G | positif | Ly6G | protein | pan-lignée | mouse | 23706740 30709741 |