Index › Hématopoïétique – myéloïde › Hematopoietic stem and progenitor cell (lineage-negative) › Common myeloid progenitor (CMP) › Granulocyte-monocyte progenitor (GMP) › Committed neutrophil progenitor (preNeu / proNeu) › Neutrophil promyelocyte › Neutrophil myelocyte / metamyelocyte › Immature (band) neutrophil › Mature neutrophil

Mature neutrophil

Terminally differentiated, short-lived granulocyte of blood; human CD66b+ CD15+ CD16+ CD10+, mouse Ly6G-high CD11b+.

Synonymes : segmented neutrophil, polymorphonuclear leukocyte, PMN

Tissus : blood, bone marrow, spleen, tissues

Cell Ontology : mature neutrophil · CL:0000096 (correspondance exacte) — A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive,

Marqueurs (12)

Sous-types

• Aged (senescent) neutrophil, CXCR4hi CD62Llo
• CD16hi CD62Llo immunosuppressive neutrophil (human)
• Reverse transendothelial migration neutrophil (CD54hi CXCR1lo)
• Tumor-associated neutrophil, N1 (anti-tumor), mouse
• Tumor-associated neutrophil, N2 (pro-tumor), mouse
• SiglecF-high infarct neutrophil (mouse heart)
• Interferon-stimulated neutrophil (G5c)

Données curées avec références PubMed/DOI, licence CC BY 4.0. « Spécifique » est calculé sur la couverture de cet atlas : vérifiez dans la littérature citée. Version interactive avec filtres et comparaison.